Panagiota Kontou

Assistant Professor · Department of Mathematics · University of Thessaly

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Publications in International Scientific Journals

  1. Tsionkis, G., Andronidou, E. M., Kontou, P. I., Tamposis, I. A., Tegopoulos, K., Pergantas, P., Grigoriou, M. E., Skavdis, G., Bagos, P. G., & Braliou, G. G. (2025). Humulus lupulus (Hop)-Derived Chemical Compounds Present Antiproliferative Activity on Various Cancer Cell Types: A Meta-Regression Based Panoramic Meta-Analysis. Pharmaceuticals, 18(8), 1139. https://doi.org/10.3390/ph18081139
  2. Kiofentzoglou, D., Andronidou, E. M., Kontou, P. I., Bagos, P. G., & Braliou, G. G. (2025). Antimicrobial Activity of Chemical Hop (Humulus lupulus) Compounds: A Systematic Review and Meta-Analysis. Applied Sciences, 15(14), 7806. https://doi.org/10.3390/app15147806
  3. Baltoumas, F. A., E. Karatzas, N. K. Venetsianou, E. Aplakidou, K. Giatras, M. Chasapi, I. N. Chasapi, I. Iliopoulos, V. A. Iconomidou, I. P. Trougakos, F. Psomopoulos, A. Giannakakis, I. Georgakopoulos-Soares, P. I. Kontou, P. G. Bagos and G. A. Pavlopoulos (2025). "Darling (v2.0): Mining disease-related databases for the detection of biomedical entity associations." Computational and Structural Biotechnology Journal.
  4. Manios, G. A., Michailidi, A., Kontou, P. I., & Bagos, P. G. (2025). PRED-LD: efficient imputation of GWAS summary statistics. BMC bioinformatics, 26(1), 107.
  5. Nikolitsa, E.K., Kontou, P.I. & Bagos, P.G. metacp: a versatile software package for combining dependent or independent p-values. BMC Bioinformatics 26, 109 (2025). https://doi.org/10.1186/s12859-025-06126-z
  6. Vogiatzoglou, A. V., Kontou, P. I., Bagos, P. G., & Braliou, G. G. (2024). Genetic association of SLC6A3 (dopamine transporter) gene polymorphisms with personality disorders and substance abuse disorders: a systematic review and meta-analysis. Psychiatric genetics, 34(5), 93-105.5
  7. Kontou, P.I., Bagos, P.G. The goldmine of GWAS summary statistics: a systematic review of methods and tools. BioData Mining 17, 31 (2024). https://doi.org/10.1186/s13040-024-00385-x
  8. Tsironis, A., Vlahou, E., Kontou, P., Bagos, P., & Kopčo, N. (2024). Adaptation to reverberation for speech perception: A systematic review. Trends in Hearing, 28, 23312165241273399.
  9. Papaefthimiou M, Kontou PI, Bagos PG, Braliou GG. Integration of Antioxidant Activity Assays Data of Stevia Leaf Extracts: A Systematic Review and Meta-Analysis. Antioxidants. 2024; 13(6):692. https://doi.org/10.3390/antiox13060692
  10. Karatzas E, Baltoumas FA, Aplakidou E, Kontou PI, Stathopoulos P, Stefanis L, Bagos PG, Pavlopoulos GA. Flame (v2.0): advanced integration and interpretation of functional enrichment results from multiple sources. Bioinformatics. 2023 Aug 1;39(8):btad490. doi: 10.1093/bioinformatics/btad490.
  11. Papaefthimiou M, Kontou PI, Bagos PG, Braliou GG. Antioxidant Activity of Leaf Extracts from Stevia rebaudiana Bertoni Exerts Attenuating Effect on Diseased Experimental Rats: A Systematic Review and Meta-Analysis. Nutrients. 2023; 15(15):3325. https://doi.org/10.3390/nu15153325
  12. Özbek M, Toy HI, Takan I, Asfa S, Arshinchi Bonab R, Karakülah G, Kontou PI, Geronikolou SA, Pavlopoulou A. A Counterintuitive Neutrophil-Mediated Pattern in COVID-19 Patients Revealed through Transcriptomics Analysis. Viruses. 2023; 15(1):104. https://doi.org/10.3390/v15010104
  13. Papathanassiou, M., I. Tamposis, K. K. Exarchou-Kouveli, P. I. Kontou, A. T. de Paz, L. Mitrakas, M. Samara, P. G. Bagos, V. Tzortzis and P. J. Vlachostergios (2022). "Immune-based treatment re-challenge in renal cell carcinoma: A systematic review and meta-analysis." Frontiers in Oncology 12: 6469.
  14. Arshinchi Bonab R, Asfa S, Kontou P, Karakülah G, Pavlopoulou A. 2022. Identification of neoplasm-specific signatures of miRNA interactions by employing a systems biology approach. PeerJ 10:e14149 https://doi.org/10.7717/peerj.14149
  15. Charitou, T., Kontou, P. I., Tamposis, I. A., Pavlopoulos, G. A., Braliou, G. G., & Bagos, P. G. (2022). Drug genetic associations with COVID-19 manifestations: a data mining and network biology approach. The Pharmacogenomics Journal. doi:10.1038/s41397-022-00289-1
  16. Tamposis, I.A.; Manios, G.A.; Charitou, T.; Vennou, K.E.; Kontou, P.I.; Bagos, P.G. MAGE: An Open-Source Tool for Meta-Analysis of Gene Expression Studies. Biology 2022, 11, 895. https://doi.org/10.3390/biology11060895
  17. Lianou, D.T.; Skoulakis, A.; Michael, C.K.; Katsarou, E.I.; Chatzopoulos, D.C.; Solomakos, N.; Tsilipounidaki, K.; Florou, Z.; Cripps, P.J.; Katsafadou, A.I.; Vasileiou, N.G.C.; Dimoveli, K.S.; Bourganou, M.V.; Liagka, D.V.; Papatsiros, V.G.; Kontou, P.I.; Mavrogianni, V.S.; Caroprese, M.; Petinaki, E.; Fthenakis, G.C. Isolation of Listeria ivanovii from Bulk-Tank Milk of Sheep and Goat Farms—From Clinical Work to Bioinformatics Studies: Prevalence, Association with Milk Quality, Antibiotic Susceptibility, Predictors, Whole Genome Sequence and Phylogenetic Relationships. Biology 2022, 11, 871. https://doi.org/10.3390/biology11060871
  18. Tapari, A.; Braliou, G.G.; Papaefthimiou, M.; Mavriki, H.; Kontou, P.I.; Nikolopoulos, G.K.; Bagos, P.G. Performance of Antigen Detection Tests for SARS-CoV-2: A Systematic Review and Meta-Analysis. Diagnostics 2022, 12, 1388. https://doi.org/10.3390/diagnostics12061388
  19. Goutzelas, Y., Kontou, P., Mamuris, Z., Bagos, P., & Sarafidou, T. (2022). Meta-analysis of gene expression data in adipose tissue reveals new obesity associated genes. Gene, 146223. Advance online publication. https://doi.org/10.1016/j.gene.2022.146223
  20. Barba E, Kontou PI, Michalopoulos I, Bagos PG, Braliou GG. "Association of ITPA gene polymorphisms with adverse effects of AZA/6-MP administration: a systematic review and meta-analysis" Pharmacogenomics J (2022). https://doi.org/10.1038/s41397-021-00255-3.
  21. Kontou, P., Pavlopoulou, A., Dimou, N., Theodoropoulou, M., Braliou, G., Tsaousis, G., ... & Bagos, P. (2021). The human GPCR signal transduction network. Network Modeling Analysis in Health Informatics and Bioinformatics, 10(1), 1-12.
  22. Yılmaz H, Toy HI, Marquardt S, Karakülah G, Küçük C, Kontou PI, Logotheti S, Pavlopoulou A. In Silico Methods for the Identification of Diagnostic and Favorable Prognostic Markers in Acute Myeloid Leukemia. International Journal of Molecular Sciences. 2021; 22(17):9601. https://doi.org/10.3390/ijms22179601
  23. Karatzas, E., M. Gkonta, J. Hotova, F. A. Baltoumas, P. I. Kontou, C. J. Bobotsis, P. G. Bagos and G. A. Pavlopoulos (2021). "VICTOR: A visual analytics web application for comparing cluster sets." Computers in Biology and Medicine 135: 104557.
  24. Toy, H. I., G. Karakülah, P. I. Kontou, H. Alotaibi, A. G. Georgakilas and A. Pavlopoulou (2021). "Investigating Molecular Determinants of Cancer Cell Resistance to Ionizing Radiation Through an Integrative Bioinformatics Approach." Frontiers in Cell and Developmental Biology 9(770).
  25. Michael, C. K., D. T. Lianou, N. G. C. Vasileiou, K. Tsilipounidaki, A. I. Katsafadou, A. P. Politis, N. G. Kordalis, K. S. Ioannidi, D. A. Gougoulis, C. Trikalinou, D. C. Orfanou, I. A. Fragkou, P. I. Kontou, D. V. Liagka, V. S. Mavrogianni, E. Petinaki and G. C. Fthenakis (2021). "Association of Staphylococcal Populations on Teatcups of Milking Parlours with Vaccination against Staphylococcal Mastitis in Sheep and Goat Farms." Pathogens 10(4): 385.
  26. Pappa, S. A., P. I. Kontou, P. G. Bagos and G. G. Braliou (2021). "Urine-Based Molecular Diagnostic Tests for Leishmaniasis Infection in Human and Canine Populations A Meta-Analysis." Pathogens 10(3): 269.:
  27. Katsarou, E. I., D. C. Chatzopoulos, T. Giannoulis, K. S. Ioannidi, A. I. Katsafadou, P. I. Kontou, D. T. Lianou, Z. Mamuris, V. S. Mavrogianni, C. K. Michael, E. Papadopoulos, E. Petinaki, S. Sarrou, N. G. C. Vasileiou and G. C. Fthenakis (2021). "MLST-Based Analysis and Antimicrobial Resistance of Staphylococcus epidermidis from Cases of Sheep Mastitis in Greece." Biology 10(3): 170.
  28. Tamposis, I. A., Sarantopoulou, D., Theodoropoulou, M. C., Stasi, E. A., Kontou, P. I., Tsirigos, K. D., & Bagos, P. G. (2021). Hidden neural networks for transmembrane protein topology prediction. Computational and Structural Biotechnology Journal, 19, 6090-6097.
  29. Kapoula, G.V.; Kontou, P.I.; Bagos, P.G. Diagnostic Performance of Biomarkers Urinary KIM-1 and YKL-40 for Early Diabetic Nephropathy, in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis. Diagnostics 2020, 10, 909.
  30. Kontou PI, Braliou GG, Dimou NL, Nikolopoulos G, Bagos PG. Antibody Tests in Detecting SARS-CoV-2 Infection: A Meta-Analysis. Diagnostics. 2020; 10(5):319.
  31. Vennou, K. E., Piovani, D., Kontou, P. I., Bonovas, S., & Bagos, P. G. (2020). Multiple outcome meta-analysis of gene-expression data in inflammatory bowel disease. Genomics, 112(2), 1761-1767. doi: 10.1016/j.ygeno.2019.09.019
  32. Vennou, K. E., Kontou, P. I., Braliou, G. G., & Bagos, P. G. (2020). Meta-analysis of gene expression profiles in preeclampsia. Pregnancy Hypertension, 19, 52-60. doi: https://doi.org/10.1016/j.preghy.2019.12.007
  33. Vennou, K. E., Piovani, D., Kontou, P. I., Bonovas, S., & Bagos, P. G. (2020). Methods for multiple outcome meta-analysis of gene-expression data. MethodsX, 7, 100834. doi: https://doi.org/10.1016/j.mex.2020.100834
  34. Tamposis, I. A., Tsirigos, K. D., Theodoropoulou, M. C., Kontou, P. I., & Bagos, P. G. (2018). Semi-supervised learning of Hidden Markov Models for biological sequence analysis. Bioinformatics, 35(13), 2208-2215. doi: 10.1093/bioinformatics/bty910
  35. Ligda, G., Ploubidis, D., Foteli, S., Kontou, P.I., Nikolaou, C. and Tentolouris, N., 2019. Quality of life in subjects with type 2 diabetes mellitus with diabetic retinopathy: A case–control study. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13(2), pp.947-952.
  36. Kapoula G, Kontou PI, Bagos PG. Diagnostic accuracy of neutrophil gelatinase-associated lipocalin (NGAL) for predicting early diabetic nephropathy in patients with Type 1 and Type 2 diabetes mellitus: A systematic review and meta-analysis. The Journal of Applied Laboratory Medicine 2019:jalm.2018.028530
  37. Halil Ibrahim Toy, Didem Okmen, Panagiota I Kontou, Alexandros G. Georgakilas, Athanasia Pavlopoulou. HOTAIR as a prognostic predictor for diverse human cancers: a meta-and bioinformatics analysis. Cancers 11.6 (2019): 778
  38. Braliou GG, Kontou PI, Boleti H, Bagos PG. Susceptibility to leishmaniasis is affected by host SLC11A1 gene polymorphisms: a systematic review and meta-analysis. Parasitology Research (2019) https://doi.org/10.1007/s00436-019-06374-y
  39. Tamposis, I. A., K. D. Tsirigos, M. C. Theodoropoulou, P. I. Kontou, G. N. Tsaousis, D. Sarantopoulou, Z. I. Litou and P. G. Bagos. "JUCHMME: a Java Utility for Class Hidden Markov Models and Extensions for biological sequence analysis." Bioinformatics. (2019) https://doi.org/10.1093/bioinformatics/btz533
  40. Pavlopoulos GA, Kontou PI (*), Pavlopoulou A, Bouyioukos C, Markou E, Bagos PG. Bipartite Graphs in Systems Biology and Medicine: a survey of methods and applications. GigaScience, Volume 7, Issue 4, 1 April 2018, giy014, https://doi.org/10.1093/gigascience/giy014 (* equal first authors)
  41. Kontou, P. I., Pavlopoulou, A., Braliou, G., Bogiatzi, S., Dimou, N., Bangalore, S. and Bagos, P., 2018. Identification of gene expression profiles in myocardial infarction: a systematic review and meta-analysis. BMC medical genomics, 11(1), p.109.
  42. Kontou P.I., Pavlopoulou A., Bagos P.G. (2018) Methods of Analysis and Meta-Analysis for Identifying Differentially Expressed Genes. In: Evangelou E. (eds) Genetic Epidemiology. Methods in Molecular Biology, vol 1793. Humana Press, New York, NY
  43. Paraskevopoulou-Kollia, E.-A., Kontou, P., Romanova, E. A., Kuznetsov, V. A., & Palios, Z. (2018). A comparative study of Greek and Russian teachers’ daily life in the classroom. Human Capital (ЧЕЛОВЕЧЕСКИЙ КАПИТАЛ), № 6(114).
  44. Paraskevopoulou-Kollia, E.-A., Soursou, G., Kontou, P., Zogopoulos, B., Oreopoulou, E., & Zoura, V. (2018). Computer Science Students’ views on Educational Studies-Pedagogy. i-manager’s Journal of Educational Technology, Vol. 15 l No. 1 l April - June 2018
  45. Kapoula G, Kontou PI, Bagos PG. (2017) The impact of pneumatic tube system on routine laboratory parameters: a systematic review and meta-analysis. Clinical Chemistry and Laboratory Medicine (CCLM), 55(12), pp. 1834-1844
  46. Kontou, P. I., Pavlopoulou, A., Dimou, N. L., Pavlopoulos, G. A., Bagos, P. G. (2016). Network analysis of genes and their association with diseases. Gene, 590(1), 68-78. doi: 10.1016/j.gene.2016.05.044
  47. Kontou PI, Pavlopoulou A, Dimou NL, Pavlopoulos GA, Bagos PG. Data and programs in support of network analysis of genes and their association with diseases. Data in Brief, 8 (2016) 1036-1039
  48. Pantavou K, Braliou GG, Kontou PI, Dimou NL, Bagos PG. A meta-analysis of FZD3 polymorphisms and their association with schizophrenia. Psychiatric genetics, 26 (2016) 272-280
  49. Braliou GG, Pantavou KG, Kontou PI, Bagos PG. Polymorphisms of the CD24 Gene Are Associated with Risk of Multiple Sclerosis: A Meta-Analysis. International Journal of Molecular Sciences. 2015.
  50. Braliou GG, Grigoriadou AM, Kontou PI, Bagos PG. The role of genetic polymorphisms of the Renin-Angiotensin System in renal diseases: A meta-analysis. Comput Struct Biotechnol J. 2014 Jun 11;10(16):1-7